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Anisomycin, also known as Flagecidin (IUPAC name: 3,4-Pyrrolidinediol,
2-[(4-methoxyphenyl)methyl]-, 3-acetate, (2R,3S,4S)-) is an antibiotic produced
by Streptomyces griseolus which inhibits protein synthesis. Partial inhibition
of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition
of protein synthesis [1]. Anisomycin can activate stress-activated protein
kinases, MAP kinase and other signal transduction pathways.
Anisomycin is inactive against bacteria.
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Public release date: 10-Dec-2002"Imagine the possible benefit for people traumatized by haunting memories of terror or tragedy. The day may come when the cure is recalling the trauma, and then erasing it with a shot", wondered Dallas Morning News reporter Tom Siegfried (Aug. 28, 2000) commenting on Dr. Karim Nader's discovery that a fear memory induced in a rat and reactivated after 1 -12 days of storage in the outer part of the brain could be eradicated with a shot of anisomycin, a protein-synthesis inhibitor. The biology of induced memory
Two years after the publication of "Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval" in the August 14, 2000 issue of Nature, Dr. Nader and his colleague from New York University , neuroscientist Joseph E. Ledoux, published in the October 24, 2002, issue of Neuron, an article which shows that the same reconsolidation process goes on in another part of the brain which mediates conscious memories, the hippocampus.
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Anisomycin is an antibiotic which inhibits Protein Synthesis. Also activates p54, MAP Kinases and Stress-Activated Protein Kinases.
Anisomycin Chemical Formula: C14H19NO4
Anisomycin Chemical Name: :
2-p-methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine
Anisomycin Molecular Weight: M.W. 265.31
Anisomycin Solubility: Soluble in DMSO and Ethyl Acetate.
Anisomycin Boiling Point / Melting Point: BP/MP: 139-141C
Handling: Warning! Toxic. LD50 of < 500 mg / kg.
anisomycin is an inhibitor of brain protein synthesis shown to have an effect on spatial memory.
"Imagine the possible benefit for people traumatized by haunting memories of terror or tragedy. The day may come when the cure is recalling the trauma, and then erasing it with a shot", wondered Dallas Morning News reporter Tom Siegfried (Aug. 28, 2000) commenting on Dr. Karim Nader's discovery that a fear memory induced in a rat and reactivated after 1 -12 days of storage in the outer part of the brain could be eradicated with a shot of anisomycin, a protein-synthesis inhibitor."
Anisomycin is approvevd For research use only. Not for human or drug use
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